Peyote's role in Indigenous spirituality is profound, acting as a sacrament that connects individuals to the divine and fosters communal healing. Its use transcends mere consumption, deeply rooted in the mythology, cosmology, and ritual practices of Native American tribes.

Different cultures have unique ceremonies involving peyote, but common themes of healing, purification, and communion with the spirit world are prevalent. For instance, the Huichol people undertake annual pilgrimages to gather peyote, a journey that is as spiritual as it is cultural. These pilgrimages are imbued with symbolic acts and storytelling, establishing a living bridge to their ancestors and spiritual lineage.

Peyote ceremonies typically occur at night, using fire rituals, chanting, and drumming to support participants' journeys through altered states buy peyote catus. These practices aim to dissolve personal and spiritual boundaries, offering insights and a sense of interconnectedness with nature, the universe, and the human community.

The Native American Church, founded in the early 20th century, institutionalized peyote's religious use. It organized its practices under a structured framework, merging Christian elements with traditional Indigenous spirituality. This synthesis provided a platform for cultural preservation amidst growing external pressures.

Peyote's sacred role underscores the importance of respecting traditions and knowledge systems that have revered and preserved its use for generations. Indigenous leaders advocate for peyote's conservation and ethical use, recognizing it as not only a spiritual sacrament but as a symbol of resilience and cultural identity.